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Natural Awakenings Spokane WA/Coeur d'Alene ID

The Power of Low-Dose Naltrexone on Chronic Conditions

Mar 01, 2020 07:46AM ● By Amber McKenzie

by Erik Nelson

Ongoing research shows that Low-Dose Naltrexone (LDN) has positive effects on those suffering from autoimmune diseases, chronic pain, mental health challenges and inflammation. Naltrexone is an opiate receptor antagonist that creates increased endorphin release which modulates the immune response and reduces the speed of unwanted cell growth. A 50 milligram dose of Naltrexone was approved by the FDA for opioid and alcohol addiction back in 1984, but when reduced to smaller doses ranging from 0.5 milligram to 9.0 milligram daily, it has the unique ability to modulate the immune system and provide relief to a multitude of health conditions, including: 

·      ALS (Lou Gehrig’s Disease)

·      Addiction

·      Alzheimer’s Disease

·      Anxiety

·      Autism Spectrum Disorders

·      Behcet’s Disease

·      COPD

·      Celiac Disease

·      Chronic Fatigue Syndrome

·      Crohn’s Disease

·      Depression

·      Eczema

·      Endometriosis

·      Fibromyalgia

·      Hashimoto’s Discease

·      Hypothyroidism

·      Irritable Bowel Syndrome (IBS)

·      Lyme Disease

·      Menier’s Disease

·      Polycystic Ovary Syndrome

·      Rheumatoid Arthritis

·      Ulcerative Colitis

For full list of conditions, visit

Over the past 10 years, there has been growing evidence that the body’s endorphins (naturally occurring opioids) play a critical role in regulating the immune system and providing pain relief. LDN’s blockade of opioid and Toll-like receptors (TLRs) has been shown to upregulate endorphin production and contribute to the anti-inflammatory and immune dampening effects, which is why LDN can be beneficial for so many patients. The key to success in administering LDN is understanding that optimal dosing is ultimately patient specific and is not dependent on a set protocol. Dosing strategies can vary tremendously with some patients finding success very quickly, while others need to try a variety of dosing strategies. LDN is available only by prescription and must be custom made at a compounding pharmacy. It is critical to work with a provider or a compounding pharmacy knowledgeable in strategies that can help ensure success with LDN.

Erik Nelson, PharmD, FAAMFM, FACA, is the owner and lead pharmacist at Sixth Avenue Medical Pharmacy located at 508 W. 6th Ave., Spokane. This ACHC accredited compounding pharmacy works closely with area medical providers and specializes in LDN patient support and education. If you have questions about LDN, contact 509-455-9345 or visit
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